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Preparing for the HESI RN 31I Pharmacology Exam requires not only memorization but a deep understanding of how drugs interact with the human body, patient care protocols, and nursing responsibilities. This specialty exam tests your knowledge in drug classifications, mechanisms of action, safe medication administration, and adverse effects—crucial areas in RN practice.

At Ulosca.com, one of the top-ranked websites for U.S. nursing exam preparation, we provide nursing students with expertly designed, exam-aligned practice resources. Whether you’re reviewing for your first HESI exam or refining your pharmacology foundation, Ulosca gives you the tools to succeed.

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Sample HESI RN 31I Pharmacology Exam Questions and Rationales

Sample HESI RN 31I Pharmacology exam questions with detailed rationales to help you understand key concepts and prepare effectively.

Question 1: Drug Classification

A client is prescribed lisinopril for hypertension. This drug belongs to which class?
A. Beta-blocker
B. ACE inhibitor
C. Calcium channel blocker
D. Alpha-2 agonist

Correct Answer: B. ACE inhibitor
Rationale: Lisinopril is an ACE (angiotensin-converting enzyme) inhibitor used to lower blood pressure by preventing the conversion of angiotensin I to angiotensin II. 

This reduces vasoconstriction. Beta-blockers slow heart rate, calcium channel blockers reduce calcium influx into muscle cells, and alpha-2 agonists decrease sympathetic outflow.

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Question 2: Mechanism of Action

What is the primary action of furosemide?
A. Reduces heart rate
B. Inhibits reabsorption of sodium and chloride in the loop of Henle
C. Increases aldosterone production
D. Stimulates beta-2 receptors in the lungs

Correct Answer: B. Inhibits reabsorption of sodium and chloride in the loop of Henle
Rationale: Furosemide is a loop diuretic that prevents sodium and chloride reabsorption, increasing diuresis. It is commonly used for edema and hypertension. The other options do not reflect furosemide’s action.

Question 3: Medication Administration

Before administering digoxin, which parameter should the nurse check?
A. Blood pressure
B. Respiratory rate
C. Apical heart rate
D. Blood glucose level

Correct Answer: C. Apical heart rate
Rationale: Digoxin can cause bradycardia. Always check the apical pulse for a full minute, and withhold if the rate is below 60 bpm. Blood pressure and glucose are important but not directly linked to digoxin safety.

Question 4: Adverse Effects

A patient taking gentamicin IV develops ringing in the ears. What action should the nurse take?
A. Document the finding as expected
B. Administer acetaminophen
C. Stop the infusion and notify the provider
D. Encourage oral fluids

Correct Answer: C. Stop the infusion and notify the provider
Rationale: Tinnitus is a sign of ototoxicity, a serious adverse effect of aminoglycosides like gentamicin. Prompt action is needed to prevent permanent hearing damage.

Question 5: Patient Education

A nurse is teaching a patient about warfarin. Which statement indicates the need for further teaching?
A. “I will avoid eating large amounts of spinach.”
B. “I will get my INR levels checked regularly.”
C. “I can take aspirin for headaches.”
D. “I will inform all healthcare providers that I’m on warfarin.”

Correct Answer: C. “I can take aspirin for headaches.”
Rationale: Aspirin increases bleeding risk when taken with warfarin. Patients should avoid NSAIDs and consult providers before taking any new medication. The other statements are correct and reflect good understanding.

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Ulosca.com is trusted by thousands of nursing students across the United States for several reasons:

  • HESI-aligned content: All materials are tailored to the HESI blueprint and clinical practice standards.
  • Comprehensive question banks: With detailed rationales and clinical reasoning support.
  • Updated regularly: To reflect changes in pharmacology practice and exam trends.
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Whether you’re preparing for RN pharmacology or other HESI specialty exams, Ulosca is your reliable, expert-driven platform.

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Conclusion

Mastering the HESI RN 31I Pharmacology Exam is an essential step toward becoming a safe, competent registered nurse. By focusing on key pharmacological principles, using practice questions to test your understanding, and reviewing in-depth rationales, you can confidently face your exam.

Ulosca.com is here to support your journey with targeted content, expert-crafted questions, and exam success strategies. Start preparing today with the platform trusted by top nursing students across the U.S.